The Simpsons is probably the most well known cartoon in the world and the series has been running steadily since the 1980's and is currently in its 25th season. This may be the reason why the writers thought it would be a great idea to start season 26 of with one of the loved characters death.
As with everything Simpsons related, there is a lot of rumours and gossip surrounding the new season, with some believing that the writers would actually kill one of the loved characters such as Krusty the Clown, Sideshow Bob or even Barney Gumble.
Realistically though, it is more likely that one of the minor characters in the series will be the one to die. Paddy Power has no doubt about who they believe is going to be killed in the series, as the "worst" odds has been placed on Krusty's dad, Rabbi Hyman Krustofsky, at odds 2.10.
Paddy Power still offers odds on several other of the main characters in the show to be killed off, which you can place a bet on on their website. You can see the odds provided by Paddy Power below:
Rabbi Hyman Krustofsky - Odds 2.10
Krusty the Clown - Odds 2.20
Sideshow Bob - Odds 6.00
Abe Simpson - Odds 8.00
Apu Nahasapeemapetilon - Odds 9.00
Barney Gumble - Odds 15.00
Willie - Odds 25.00
Chief Wiggum - Odds 33.00